Regulatory T Cells: Mechanisms of Differentiation and Function (Annual Review of Immunology Book 30) Steven Z. Josefowicz

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Published: November 28th 2012

Kindle Edition

47 pages


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Regulatory T Cells: Mechanisms of Differentiation and Function (Annual Review of Immunology Book 30)  by  Steven Z. Josefowicz

Regulatory T Cells: Mechanisms of Differentiation and Function (Annual Review of Immunology Book 30) by Steven Z. Josefowicz
November 28th 2012 | Kindle Edition | PDF, EPUB, FB2, DjVu, talking book, mp3, RTF | 47 pages | ISBN: | 7.28 Mb

The immune system has evolved to mount an effective defense against pathogens and to minimize deleterious immune-mediated inflammation caused by commensal microorganisms, immune responses against self and environmental antigens, and metabolicMoreThe immune system has evolved to mount an effective defense against pathogens and to minimize deleterious immune-mediated inflammation caused by commensal microorganisms, immune responses against self and environmental antigens, and metabolic inflammatory disorders.

Regulatory T (Treg) cell–mediated suppression serves as a vital mechanism of negative regulation of immune-mediated inflammation and features prominently in autoimmune and autoinflammatory disorders, allergy, acute and chronic infections, cancer, and metabolic inflammation. The discovery that Foxp3 is the transcription factor that specifies the Treg cell lineage facilitated recent progress in understanding the biology of regulatory T cells.

In this review, we discuss cellular and molecular mechanisms in the differentiation and function of these cells.



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